Dr. John H. Zhang, MD, PhD, FAHA is an internationally renowned research scholar who has dedicated his career to advance the field of neuroscience and stroke research for over 25 years. Dr. Zhang is currently a Professor of Neurosurgery, Anesthesiology, Physiology as well as the Physiology Program Director at Loma Linda University School of Medicine in Loma Linda, California. Dr. Zhang is also the Director of Center for Neuroscience Research at Loma Linda University which provides research opportunities for medical and graduate students, postdoctoral fellows, visiting research scholars and junior faculty members. The primary focus of Dr. Zhang’s lab has been to increase the understanding of pathophysiological mechanisms of stroke and cerebrovascular diseases and to identify new therapeutic targets for clinical translation. Dr. Zhang has published more than 800 research articles in peer reviewed journals. He has edited and published 25 books on stroke and central nervous system injuries and guest edited 24 special journal issues on stroke. Dr. Zhang serves on the editorial board of prestigious journals and he is also the founding editor of Translational Stroke Research and Medical Gas Research journals.
Various research directions are currently being pursued in the Zhang Lab. The lab utilizes stroke models that mimic clinical scenarios in patients such as subarachnoid hemorrhage, intracerebral hemorrhage, ischemic stroke, neonatal brain injury and surgical brain injury. Ongoing research areas in the subarachnoid hemorrhage field include exploring mechanisms of neuronal apoptosis, cell death, neurovascular injury, blood brain barrier permeability and inflammatory response which contribute to early brain injury. The role of cerebrovenous circulation in subarachnoid hemorrhage pathophysiology is a new research direction that is being pursued in the lab. Another interesting research direction that the Zhang Lab has pioneered is the potential of applying delayed recanalization after ischemic stroke. The lab is also conducting studies to elucidate mechanisms of hematoma expansion and blood toxicity after intracerebral hemorrhage. Additionally, various projects are being pursued to explore novel therapeutic strategies to remove hematoma in adult and neonatal hemorrhagic stroke models. Another novel area pioneered in the Zhang Lab includes the study of neurosurgical injury and the potential applications of preconditioning to reduce perisurgical brain tissue injury. Overall, the primary goal of Zhang Lab has been to perform studies with the potential for clinical translation.
Dr. Zhang’s invaluable contribution to science has been recognized and has received numerous accolades. He has received research grants from prestigious institutions such as the National Institutes of Health, American Heart Association and Department of Defense to support his research efforts. Dr. Zhang received awards such as the Lifetime Achievement Award for Subarachnoid Hemorrhage Research in 2011, Distinguished University Investigator Award at Loma Linda University in 2015 and Chinese Stroke Award by Chinese Stroke Association in 2015. He also received major honors as President of the International Society of SAH Research in 2015 and as President of International Brain Edema Society in 2014. Dr. Zhang continues to inspire upcoming new researchers to pursue new discoveries in the field of neuroscience research.